Computational Comparative Genomics Lab

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

Welcome to the Computational Comparative Genomics Lab led by Jian Ma in the Department of Bioengineering and the Institute for Genomic Biology at the University of Illinois at Urbana-Champaign.

The success of the Human Genome Project has ushered in a new era in which biology has become an information science. More recently, the rapid advancement in ultra high-throughput DNA sequencing technologies underlines the urgent need for more innovative computational research in modern biology, for generating, analyzing, and understanding massive amount of genomic data to develop and evaluate biological hypotheses.

Our long-term research goal is to understand how phenotype (at the cellular and organism levels) is generated from genotype and to shed new light on disease mechanisms, such as cancer. Our interdisciplinary work combines genomics, computational innovation, engineering principles, and medical sciences. We develop novel computational methods to explore the human genome, integrating comparative genomics data to elucidate cross-species differences and within-species variation and their associations with disease. We develop new systems biology approaches to identifying key genetic variants in cancer development and progression using high-throughput next-generation sequencing technologies.

[Postdoc position available] - We are also looking for new Ph.D. students (BIOE, Biophysics, and CS).

What's New

06/27/2014.
Ken and Yang Zhang's TFBS evolution paper accepted by PLOS Computational Biology.
05/12/2014.
Brittany has been selected as an M-CNTC trainee (co-advised with Ning Wang and Taekjip Ha).
05/08/2014.
Jack has been selected as a CSE Fellow (2014-2015).
03/20/2014.
Yang Zhang received the Yee Memorial Fund Fellowship.
03/13/2014.
Jack was the runner-up in TBS reality show "King of the Nerds" (Season 2).
09/03/2013.
Led by Robinson and Stubbs, IGB GNDP theme received a $3M grant from the Simons Foundation.
07/30/2013.
Collaboration with Gene Robinson gets published as a cover story in PNAS.
05/24/2013.
We have a 3-year NSF ABI Innovation grant that has been recommended for funding.
05/16/2013.
Collaboration with Olgica Milenkovic and Huimin Zhao received SRI funding.
01/10/2013.
RACA is published in PNAS [news] [software].
05/14/2012.
We received a 2-year grant from the Interdisciplinary Innovation Initiative (In3) program.
05/11/2012.
We received a Junior Cancer Investigator Pilot grant from UI Cancer Center to study prostate cancer.
02/21/2012.
We received an R21 grant from NIH/NHGRI to study conserved non-coding elements.
02/01/2012.
Jaebum joined Konkuk University (Seoul, Korea) as an Assistant Professor.
12/01/2011.
Jian is named one of "Tomorrow's PIs" by Genome Technology magazine [cover].
11/16/2010.
We will receive a 5-year NSF CAREER Award.
08/16/2009.
We received a faculty fellowship from NCSA.
08/16/2009.
Our lab started officially.