The success of the Human Genome Project has ushered in a new era in which biology has become an information science. More recently, the rapid advancement in ultra high-throughput DNA sequencing technologies underlines the urgent need for more innovative computational research in modern biology, for generating, analyzing, and understanding massive amount of genomic data to develop and evaluate biological hypotheses.
Our long-term research goal is to understand how phenotype (at the cellular and organism levels) is generated from genotype and to shed new light on disease mechanisms, such as cancer. Our interdisciplinary work combines genomics, computational innovation, engineering principles, and medical sciences. We develop novel computational methods to explore the human genome, integrating comparative genomics data to elucidate cross-species differences and within-species variation and their associations with disease. We develop new systems biology approaches to identifying key genetic variants in cancer development and progression using high-throughput next-generation sequencing technologies.
© 2009-2015 Ma Laboratory | Department of Bioengineering | Institute for Genomic Biology | University of Illinois at Urbana-Champaign