Computational Comparative Genomics Lab

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

Welcome to the Computational Comparative Genomics Lab led by Jian Ma in the Department of Bioengineering and the Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign.

Our long-term research goal is to develop novel computational methods to address a fundamental challenge in biology and biomedicine, i.e., how the changes in genome sequence give rise to the differences in phenotypes (at both cellular and organism levels). Such insights will shed new light on disease mechanisms. We develop novel algorithms to explore the human genome, integrating comparative genomics to identify different types of genomic changes in order to study their impact on genome function, chromatin and nuclear genome organization, and gene regulation. We develop new systems biology approaches to identifying key genetic variants that perturb gene regulation in cancer development and progression using high-throughput next-generation sequencing technologies.

What's New

07/15/2015.
Together with the Schwartz Lab, we received a multi-PI IMAT R33 grant from NIH/NCI.
07/03/2015.
Yang Li has successfully defended his PhD dissertation and is joining Invitae.
05/15/2015.
Jian is promoted to Associate Professor with tenure (effective 08/16/2015; pending BOT approval).
02/03/2015.
Yang Li received "Chinese Government Award for Outstanding Self-financed Students Abroad".
11/21/2014.
Jian was selected as a CAS Fellow.
08/18/2014.
We received an R01 grant from NIH/NHGRI.
06/27/2014.
Ken and Yang Zhang's TFBS evolution paper accepted by PLOS Computational Biology.
05/12/2014.
Brittany has been selected as an M-CNTC trainee (co-advised with Ning Wang and Taekjip Ha).
05/08/2014.
Jack has been selected as a CSE Fellow (2014-2015).
03/20/2014.
Yang Zhang received the Yee Memorial Fund Fellowship.
03/13/2014.
Jack was the runner-up in TBS reality show "King of the Nerds" (Season 2).
09/03/2013.
Led by Robinson and Stubbs, IGB GNDP theme received a $3M grant from the Simons Foundation.
07/30/2013.
Collaboration with Gene Robinson gets published as a cover story in PNAS.
05/24/2013.
We have a 3-year NSF ABI Innovation grant that has been recommended for funding.
05/16/2013.
Collaboration with Olgica Milenkovic and Huimin Zhao received SRI funding.
01/10/2013.
RACA is published in PNAS [news] [software].
05/14/2012.
We received a 2-year grant from the Interdisciplinary Innovation Initiative (In3) program.
05/11/2012.
We received a Junior Cancer Investigator Pilot grant from UI Cancer Center to study prostate cancer.
02/21/2012.
We received an R21 grant from NIH/NHGRI to study conserved non-coding elements.
02/01/2012.
Jaebum joined Konkuk University (Seoul, Korea) as an Assistant Professor.
12/01/2011.
Jian is named one of "Tomorrow's PIs" by Genome Technology magazine [cover].
11/16/2010.
We will receive a 5-year NSF CAREER Award.
08/16/2009.
We received a faculty fellowship from NCSA.
08/16/2009.
Our lab started officially.