Our long-term research goal is to develop novel computational methods to address
a fundamental challenge in biology and biomedicine, i.e., how the changes in genome sequence
give rise to the differences in phenotypes (at both cellular and organism levels).
Such insights will shed new light on disease mechanisms.
We develop novel algorithms to explore the human genome,
integrating comparative genomics to identify different types of genomic
changes in order to study their impact on genome function, chromatin and
nuclear genome organization, and gene regulation.
We develop new systems biology approaches to identifying key genetic
variants that perturb gene regulation in cancer development and
progression using high-throughput next-generation sequencing technologies.
Together with Belmont (contact PI), van Steensel, Gilbert, and Zhao, we received a U54 center grant from the
NIH 4D Nucleome
Our lab will lead the computational development and modeling in the center.
Yang Li has successfully defended his PhD dissertation and is joining Invitae
Jian is promoted to Associate Professor with tenure (effective 08/16/2015; pending BOT approval).
Yang Li received "Chinese Government Award for Outstanding Self-financed Students Abroad".
We received an R01 grant from NIH
Jack has been selected as a CSE Fellow
Yang Zhang received the Yee Memorial Fund Fellowship.
Led by Robinson and Stubbs, IGB GNDP theme received a $3M grant from the Simons Foundation
We have a 3-year NSF
ABI Innovation grant that has been recommended for funding.
We received a 2-year grant from the Interdisciplinary Innovation Initiative (In3
We received a Junior Cancer Investigator Pilot grant from UI Cancer Center
to study prostate cancer.
We received an R21 grant from NIH
to study conserved non-coding elements.
We received a faculty fellowship from NCSA
Our lab started officially.