Welcome to the Computational Comparative Genomics Lab led by Jian Ma in the Department of Bioengineering and the Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign.
Our long-term research goal is to develop novel computational methods to address a fundamental challenge in biology and biomedicine, i.e., how the changes in genome sequence give rise to the differences in phenotypes (at both cellular and organism levels). Such insights will shed new light on disease mechanisms. We develop novel algorithms to explore the human genome, integrating comparative genomics to identify different types of genomic changes in order to study their impact on genome function, chromatin and nuclear genome organization, and gene regulation. We develop new systems biology approaches to identifying key genetic variants that perturb gene regulation in cancer development and progression using high-throughput next-generation sequencing technologies.
© 2009-2015 Ma Lab | Dept of Bioengineering | Carl R. Woese Institute for Genomic Biology | University of Illinois at Urbana-Champaign